Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent
نویسندگان
چکیده
Biomechanical properties of a vascular graft scaffold can be optimized by studying the effect of genipin crosslinker. Collagen-based scaffolds were prepared from a mixture of rat tail collagen, chitosan and bovine aortic elastin and crosslinked with varying concentrations of genipin. Biomechanical testing results showed that the linear modulus of the uncrosslinked samples had the least modulus (84.75 kPa ± 26.45 kPa) while crosslinked scaffolds exhibited much higher linear moduli. Similar increase was observed for the ultimate strength. However, an un-crosslinked sample exhibited the best compatibility with arterial smooth muscle cells (SMC) because increase in concentration of genipin decreased SMC contraction. These studies show superior biomechanical properties can be achieved by balancing mechanical and biological properties of the scaffold with an appropriate crosslinking condition.
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